Health hazards: It is irritating to the skin and mucous membranes, and has an anesthetic effect on the central nervous system.
Acute poisoning: Inhalation of higher concentrations of this product within a short period of time can cause obvious eye and upper respiratory tract irritation, conjunctival and pharynx congestion, dizziness, headache, nausea, vomiting, chest tightness, weakness of limbs, staggering gait, and confusion. Severe patients may have restlessness, convulsions, and coma.
Chronic poisoning: Long-term exposure can cause neurasthenia syndrome, hepatomegaly, and menstrual abnormalities in female workers. Dry skin, chapped, dermatitis.
Environmental hazards: serious harm to the environment, pollution to the air, water environment and water sources.
Explosion hazard: The product is flammable and irritating. [2]
Toxicological information
Toxicity: It is a low-toxicity category.
Acute toxicity: LD50 5000mg/kg (rat oral); LC50 12124mg/kg (rabbit percutaneous); human inhalation 71.4g/m3, short-term death; human inhalation 3g/m3×1-8 hours, acute poisoning; human Inhalation of 0.2～0.3g/m3×8 hours, symptoms of poisoning appear.
Irritating:
Human eye: 300ppm, cause irritation.
Rabbit percutaneous: 500mg, moderate irritation.
Subacute and chronic toxicity: rats and guinea pigs inhale 390 mg/m3 for 8 hours/day for 90 to 127 days, causing changes in the hematopoietic system and substantial organs.
Mutagenicity: Micronucleus test: 200 mg/kg orally in mice. Cytogenetic analysis: rats inhaled 5400μg/m3 for 16 weeks (intermittent).
Reproductive toxicity: rat inhalation minimum toxic concentration (TCL0): 1.5g/m3, 24 hours (1 to 18 days of pregnancy), causing embryo toxicity and abnormal muscle development. Mice inhaled the lowest toxic concentration (TCL0): 500mg/m3, 24 hours (6 to 13 days of pregnancy), causing embryo toxicity.
Teratogenicity: Female rats inhaled the lowest toxic dose (TCLo) 1800ppm from 7 to 20 days after pregnancy, causing developmental malformations of the central nervous system. The lowest toxic dose (TCLo) of 8700 mg/kg oral administration of female mice 6-15 days after pregnancy caused craniofacial (including nose and tongue) developmental abnormalities. Female rabbits inhaled the lowest toxic dose (TCLo) 100ppm (6h) 6 to 18 days after pregnancy, resulting in malformations of the genitourinary system.
Toxicity description: It has an anesthetic effect and has a stronger skin irritation effect than benzene. When toluene vapor is inhaled, it has a stronger effect on the central nervous system than benzene. When toluene vapor with a concentration of 376~752mg/m3 is inhaled for 8 hours, symptoms such as fatigue, nausea, delusions, malfunctions, general weakness, and lethargy will appear. Short-term inhalation of toluene vapor with a concentration of 2256mg/m3 can cause excessive fatigue, intense excitement, nausea, and headaches. Long-term inhalation of low-concentration toluene vapor can cause chronic poisoning, causing loss of appetite, fatigue, leukopenia, and anemia. Toluene can also be absorbed through the skin to dissolve fat in the skin, and direct contact with the skin should be avoided. The pure product has no effect on the hematopoietic system and chromosome damage. The olfactory threshold concentration is 140mg/m3. TJ36-79 stipulates that the maximum allowable concentration in the air of the workshop is 100mg/m3.