It is derived from the reaction of trimethylamine and ethylene oxide.
Add the trimethylamine ethanol solution to the reaction pot, pass ethylene oxide at about 30°C, stir and react for 4h, and neutralize it with hydrochloric acid (control pH 6.5-7.0). The yield of crude product can reach 98%. 70% aqueous solution can be obtained by decolorization by activated carbon and concentration in vacuum. Adding excipients such as corn cob powder, rice husk powder, bran or diatomaceous earth to the aqueous solution can produce 50% powder.
Chloroethanol method
Use chloroethanol instead of ethylene oxide and hydrochloric acid, and react with trimethylamine under the catalysis of a small amount of ethylene oxide or alkaline substances: first add 100 parts of chloroethanol to the reactor, and add 130 parts of trimethylamine from the liquid surface. Simultaneously, 1.7 parts of ethylene oxide was introduced to initiate the reaction. After the addition, the temperature was kept at 32-38°C and stirred for 4 hours, and the yield was 84% (calculated as chloroethanol). If it is catalyzed by alkaline substances (such as quaternary ammonium salts), the single-pass conversion rate can reach more than 97%.