Sulbactam sodium has a synergistic antibacterial effect when combined with penicillin and cephalosporin antibiotics. The minimum inhibitory concentration (MIC) of Staphylococcus aureus, influenza bacilli, Escherichia coli, and fragile bacillus resistant to penicillin and cephalosporin antibiotics can be reduced to a sensitive range.
When sulbactam sodium is used in combination with aminoglycoside antibiotics, it has a synergistic antibacterial effect.
Probenecid can reduce renal excretion of sulbactam, and when used in combination, can increase the blood concentration of sulbactam.
Allopurinol combined with sulbactam sodium can increase the incidence of rash.